Sheboygan is a city in and the county seat of Sheboygan County, Wisconsin, United States. The population was 49,288 at the 2010 census. It is the principal city of the Sheboygan, Wisconsin Metropolitan Statistical Area. The city is located on the western shore of Lake Michigan at the mouth of the Sheboygan River, about 50 mi north of Milwaukee and 64 mi south of Green Bay.